To date, gentamicin in injections is considered a strong antibiotic of a wide spectrum of action. Getting inside the cells of bacteria through the membrane, gentamicin specifically depresses the synthesis of the protein of the pathogen. Highly active against Pseudomonas aeruginosa, gram-negative bacteria and Gram-positive cocci, including those resistant to other types of antibiotics.
Form release and composition Gentamycin
The drug is available in the form of ointment, eye drops, powder for the preparation of injection solution, liquid for injections (gentamycin sulfate). The composition of the latter, in addition to the main substance, includes:
- sodium metabisulfite;
- sodium hydroxide;
- sulfuric acid;
- disodium salt.
Indications for use Gentamycin
The drug Gentamicin, usually used in severe infections. It is effective in the treatment of patients with low immunity, which is characteristic for patients with diabetes, leukemia, etc.
Parenteral Gentamicin is used in the treatment of:
- infectious diseases of bone tissue and joints, skin (including extensive burns and frostbite );
- complicated respiratory diseases and ENT organs;
- severe inflammation in the urinary tract and abdominal cavity;
- infections of the central nervous system.
Gnatamycin injections are often used in gynecology. In inflammatory processes in the appendages in women, the drug is administered intravenously. Thanks to the use of an antibiotic, it is possible to prevent severe gynecological complications, including infertility .
Instructions for use Gentamicin in ampoules
The drug Gentamicin can be administered to the patient's body both intravenously and intramuscularly. For intravenous use, a single dose of the drug is diluted with 50-100 ml of isotonic chloride solution or the same amount of a 5% solution of glucose. The instructions state that the daily dose of Gentamicin in adult injections is 3 to 5 mg per 1 kg of body weight, for children over 14 years of age it is 0.8 to 1.2 mg per kg of body weight, with this amount being divided into 2 to 4 doses . The course of treatment is 7 to 10 days. The attending physician can make adjustments based on the severity of the disease, the age of the patient, and so on. He also determines the duration of the therapeutic course, which, in especially severe cases, can be prolonged.
Contraindications and side effects of injections Gentamycin
The use of Gentamicin is inadmissible:
- with increased sensitivity of the patient to the antibiotics of the aminoglycoside group;
- violations of kidney function;
- neuritis of the auditory nerve;
- during pregnancy and lactation.
In the treatment of Gentamicin, the following adverse events can occur:
- nausea, vomiting;
- headache;
- muscle weakness;
- convulsions;
- skin allergic reactions;
- auditory disorders;
- loss of sense of balance.
The drug is capable of cumulation, therefore, with functional kidney disorders, renal lesions are often noted.
In some cases Gentamicin is quite toxic to the patient's body. An adverse effect of the drug on the nerve endings associated with the operation of the hearing and vestibular apparatus was noted. In this connection, the patient should be under the control of the doctor, especially when the maximum dose of the drug is prescribed or the course of therapy is prolonged. Gentamicin is not prescribed in combination with antibiotics that have a nephro- or ototoxic effect. And although there is no precise data on the interaction of gentamicin and alcohol injections, specialists are strongly advised to refrain from drinking during the entire treatment period.