Tablets Nizoral have a systemic antifungal effect. Like most of these drugs, this drug can have a number of side effects. Nevertheless, these pills are the most effective in combating a variety of diseases.
How do Nizoral tablets work?
Ketoconazole is the active ingredient in Nizoral tablets. Each tablet contains 200 mg of ketoconazole, as well as other excipients:
- magnesium stearate;
- polyvidone;
- corn starch;
- microcrystalline cellulose.
Ketoconazole, getting into the gastrointestinal tract, is quickly absorbed into the blood, and after a while it is distributed among the tissues. This substance accumulates in considerable concentration in the nails and in the skin, but in addition, it can also enter the brain, overcoming the blood-brain barrier, but in an amount that is not sufficient to provide a therapeutic effect.
"Faced" with a fungal infection, the drug Nizoral inhibits the biosynthesis of ergosterol, and also changes the composition of other lipid components in mushroom cells. This suppresses their vital activity or leads to their quick death. After this, this agent decomposes in the liver, and then is excreted in the urine or through the intestine.
Application of tablets Nizoral
Nizoral is active against fungi that cause skin infections, yeast-like fungi, including all fungi of the genus Candida, and to fungi that provoke the appearance of systemic fungal damage to the human body. That's why according to the instructions Nizoril tablets are effective at:
- fungal infections of the skin (microsporia, inguinal epidermophytosis , colorful lichen, epidermophytia of feet and hands, trichophytosis);
- mycosis of the skin, soft tissues and nail plates;
- fungal infections of the scalp, as well as the mucosa of the gastrointestinal tract;
- systemic mycoses.
You can use tablets Nizoral and from thrush during a relapse and even when local therapy is ineffective. Also, this drug is used for other ailments, when local treatment can not be prescribed because the area of the affected areas is large or the depth of the lesion is very significant.
Take Nizoral tablets inside during any of the meals. This facilitates a faster absorption of the drug. Duration of the drug and its dose is different for each disease. Most often, the treatment is carried out continuously, until the symptoms of the disease completely disappear and the recovery is not confirmed with the help of a laboratory study.
Contraindications to the use of Nizoral tablets
According to the instructions for use, Nizoral tablets can not be used:
- acute or chronic liver disease;
- in the period of gestation and during lactation;
- at enzymatic disorders (for example, with lactose intolerance or lack of enzyme lactase);
- with increased sensitivity to any components of the drug;
- simultaneously with drugs that have a toxic effect on the liver or cause any disturbance of the heart rhythm.
Also, with caution, it is prescribed to those who have lowered the acidity of the stomach. Do you take drugs that lower the acidity of gastric juice? They cost to take in 2-2.5 hours after you have completed the reception of Nizoral.
Do not use Nizoral tablets against nail fungus or fungal skin infections, when the patient has adrenal insufficiency or is under stress. It is forbidden to carry out treatment with this drug and for those who abuse alcohol, as this can cause the appearance of a disulfiram-like reaction: swelling, redness of the face, nausea, rash and headache.