Bisoprolol analogues

Bisoprolol is a drug that is often prescribed to patients with cardiovascular diseases and hypertension.

Indications for its use are as follows:

• ischemic heart disease ( angina );
• arterial hypertension;
• sinus tachycardia;
• chronic heart failure;
• heart rhythm disturbances;
• arrhythmia with thyrotoxicosis and mitral valve prolapse.

Like other medications, bisoprolol has its analogues. Their main effect is identical, they all reduce blood pressure. But there are differences between them.

What can replace bisoprolol?

Analogues of the drug Bisoprolol are as follows:

• Metoprolol;
• Carvedilol;
• Egilok;
• Betaxolol;
• Nebivolol;
• Propranolol.

Further we will consider, in what a difference between medicines-analogues of Bisoprolol.

What is better - metoprolol or bisoprolol?

Metoprolol is a cheap analogue of bisoprolol. So, the indications for its use are practically the same. So is there a difference between these drugs? It turns out there is. Comparing their pharmacological properties, one can come to the conclusion that bisoprolol has a number of advantages, which we will discuss further.

The half-life of Bisoprolol is 10-12 hours, and in Metoprolol it is 3-4 hours. Due to this, bisoprolol can be taken once a day, the frequency of metoprolol intake is accordingly greater.

The binding of metoprolol to plasma proteins is 88%, while in Bisoprolol this index reaches only 30%. And than this indicator is less, the preparation is more effective. Accordingly, bisoprolol is more effective.

Bisoprolol is an amphophilic beta-blocker, it is soluble in both water and fats. Therefore, Bisoprolol slightly penetrates the blood-brain barrier and is equally deduced by the kidneys and liver. While metoprolol is excreted only by the liver, accordingly, the load on this organ will be greater.

Carvedilol or bisoprolol - which is better?

Carvedilol is another analogue of Bisoprolol. Like metoprolol, carvedilol is metabolized exclusively in the liver. Therefore, in patients with liver disease, the frequency of drug intake and dosage should be reduced. Unlike Bisoprolol, Carvedilol as well as Metoprolol penetrates the blood-brain barrier, resulting in a number of side effects from the central nervous system.

Bisoprolol or Egiloc - which is better?

Approximately 5% of the drug Egilok are excreted from the body with urine. The rest is taken out by the liver. Therefore, dosage adjustment is also necessary if there are problems with this organ. In other respects, the action of the drugs is identical, and one can safely replace one another.

Thus, it can be concluded that the actions of the drugs examined are similar. All of them lower blood pressure and heart rate. But studies were conducted in which patients were recorded at a level of blood pressure during the day. So, as a result, it was found that the drug Bisoprolol retained its hypotensive effect in the morning hours of the next day. Other analogues could not boast of this. They completely stopped or reduced their blood pressure lowering action 3-4 hours before the next dose of the drug had to be taken.

Also, studies have shown that Bisoprolol effectively controls blood pressure and heart rate both in a calm state and under physical exertion. By results of researches it is proved, that in this case Bisoprolol is more effective, than Metoprolol.