Due to the fact that most antibacterial drugs can be purchased without a doctor's prescription, their uncontrolled use increases. This entails the development of resistance of microorganisms to the medicines of this group and the inefficiency of standard therapy. Therefore, 4 generation cephalosporins have been developed that retain activity against almost all bacteria resistant to antibiotics of earlier versions.
Cephalosporin preparations of the 1 st and 4 th generation
The main difference between the drugs under consideration and their predecessors is that the 4th generation cephalosporins act on more microorganisms, both gram-positive and gram-negative. In addition, they are effective against cocci, rods and anthra bacteria, completely resistant to antibiotics of the 3rd generation.
Due to the listed features and advantages, the cephalosporins of the described species are used in the complex chemical therapy of acute and chronic inflammatory skin diseases, digestive, urogenital system, pelvic organs, joints and bones.
Despite the relative safety of these antibiotics, they produce many side effects, among which there are quite often allergic reactions, digestive disorders, decreased activity of the immune system. Therefore, cephalosporins of the 4th generation are rarely prescribed to women with hormonal disorders, including pregnant women, with dysbacteriosis, irritable bowel syndrome , and autoimmune problems. The admission of the described antibiotic drugs can only exacerbate the course of the disease.
List of 4th generation cephalosporins
To date, we know about 10 varieties of such drugs, but most of them are still in the research stage, and only 2 types are allowed to mass production: cefpir and cefepime. These antibiotics are active active substances in many names of medicines.
The names of cephalosporins are 4 generations:
- Isodep;
- Cefepime;
- Maksipim;
- Cephanorm;
- Ladef;
- Movizar;
- Cefepime;
- Maksitsef;
- Cefomax;
- We chain;
- Cefepim Alkem;
- Cephepim Jodas;
- Cefepim Agio;
- Etipim.
It should be noted that the antibodies of the 4th generation cephalosporins are produced in ampoules with a solvent, complete with a powder for the preparation of a drug suspension. The fact is that the drugs work only with intramuscular injection, as much as possible absorbed into the blood and lymph. Cephalosporins of 4 generations are not produced in tablets, because their molecular structure does not allow active substances to penetrate into the cellular structures of the intestinal mucosa and digestive tract, antibiotics are destroyed even when ingested in the stomach due to the high acidity of the stomach .
An important achievement in the production of the cephalosporins examined is that they can be stored for a long time even after
For a pronounced and sustainable result of treatment, it is important to follow the correct scheme - inject the suspension every 12 hours (intramuscularly), preferably at the same time. Also, do not exceed the recommended duration of the course, which usually ranges from 7 to 10 days. Otherwise, it is possible to intoxicate the body with antibiotics, hepatological damage to the liver and kidney pathology.