Enam is considered one of the most powerful and quality antihypertensive drugs. Indications for the use of Enam are limited, since the remedy is considered to be narrowly focused. It is thanks to this that the drug is not only very effective, but also operative.
The mechanism of action of Enam
The main active substance in the preparation is enalapril maleate. It is this component, getting into the body, is metabolized and turns into a more efficient and quick-acting substance - enalaprilat.
In addition to enalapril, Enam contains the following components:
- zinc stearate;
- maleic acid;
- anhydrous lactose.
The drug acts quite simply: after the release of enalaprilat, the body inhibits the production of angiotensin-converting enzymes. Due to this, the transformation of angiotensin I into angiotensin II is prevented. And accordingly, the overall peripheral resistance of the vessels decreases, the systolic and diastolic pressure decreases. The great advantage of Enam is that its application does not affect the development of reflex tachycardia in any way.
Produces medicament and other effects:
- strengthens blood circulation in the kidneys;
- activates depressor systems;
- oppressor pressor systems;
- reduces left ventricular hypertrophy;
- significantly reduces the need for myocardium in oxygen;
- improves the condition of the heart muscle with hypoxia.
It is important to note the fact that the intake of Enam does not affect the lipid and carbohydrate metabolism. For some categories of patients, this criterion for choosing medicines is one of the most important.
No matter what Enam tablets are taken, they start to act within a few minutes after ingestion. The maximum concentration of enalaprilat in the body is reached within three to four hours. The removal of the main components of the Enam corresponds to the kidneys. The body cleanses after about 11-12 hours.
The main indications for the application of Enam
Enam is one of the potent drugs that experts do not recommend to use uncontrolled. The main indication for the application of Enam - at elevated pressure. Recently, a growing number of doctors have given preference to the treatment of hypertension with this medication. The strength of the Enam also lies in the fact that it allows you to fight with different types of hypertension, including those with renovascular, and essential arterial hypertension.
The drug has proven itself in the treatment of diseases such as:
- chronic heart failure ;
- coronary ischemia.
To combat these diagnoses, Enam can be used as an independent treatment, but in general the drug becomes part of a combination therapy.
Practice has also confirmed the effectiveness of the medication as a means for preventing the above-described diseases.
Contraindications to the use of Enam
A medicament for oral administration is intended. The maximum daily dose of Enam is 40 mg. Use the drug is recommended once a day, regardless of food intake.
As with many pharmaceuticals, Enam does not fit all patients. Contraindicated drug when:
- aortic stenosis;
- pregnancy;
- breastfeeding;
- the possibility of angioedema development on the background of treatment with ACE inhibitors;
- individual intolerance of the individual components of the formulation.
With extreme caution, Enam needs people with such diagnoses:
- hypovolemia;
- violation of water-salt balance;
- stenosis of the renal arteries;
- syndrome of malabsorption of glucose-galactose.