In high doses, papaverine reduces the excitability of the heart muscle, slows cardiac conduction, and has a mild sedative effect. Papaverine hydrochloride is available in the form of tablets, injection solutions and suppositories.
Indications for the use of suppositories with papaverine
Papaverine is used to relieve spasms of smooth muscles and as an anesthetic in case pains are caused by spasms. When using rectal suppositories with papaverine, due to increased body temperature and good blood supply of this area, the candles dissolve quickly enough, and the drug is absorbed and enters the bloodstream. The effect from the effects of candles usually comes faster than with oral administration of the drug, in the form of tablets. Also, with this introduction, the drug also has an intense local effect. Therefore, with spasms of smooth muscles of the abdominal cavity (spasm of the urinary tract, spastic colitis, cholecystitis), the intestinal tract, pelvic organs, hemorrhoids, most often papaverine is used in candles. In addition, the use of candles with papaverine is less likely the occurrence of side effects and overdose.
Contraindications and side effects of suppositories with papaverine
When taking papaverine, especially with high dosage, individual intolerance of the drug, redness and itching of the skin due to vasodilation, dizziness and drowsiness caused by a sharp decrease in blood pressure, slowing of the heart rhythm can be observed.
The drug is not used for violation of cardiac conduction (blockade), increased intraocular pressure (glaucoma), marked renal or hepatic insufficiency.
When using papaverine, you should not smoke and drink alcohol. Nicotine reduces the effectiveness of the drug, and significantly. The combination of papaverine with alcohol can cause a sharp drop in pressure, fainting .
Candles with papaverine in hemorrhoids
With hemorrhoids papaverine is used almost exclusively in the form of rectal suppositories. As mentioned above, the candle introduced into the rectum begins to act quickly, removing the spasm and producing a local anesthetic effect. Also, candles with papaverine have a mild laxative effect, when hemorrhoids are accompanied by spastic constipation. If the patient has atonic constipation, then use of such candles is not recommended, since they can strengthen constipation and cause deterioration of the general condition.
Candles with papaverine in pregnancy
Although the instructions to the drug and indicated that its use during pregnancy and lactation is not recommended, papaverine in candles is often prescribed to pregnant women with an increased tone of the uterus. Contraindications are associated with the likelihood of cardiotoxic effects on the fetus, but when the drug is used in therapeutic doses, this possibility is extremely small. On the other hand, candles with papaverine have the most mild effect and the least amount of side effects compared to other analogs of this drug.
How to put candles with papaverine?
Suppositories with papaverine are produced in a dosage of 20 and 40 μg of the drug in one candle. It is always advisable to start treatment with a lower dosage, and increase it only if the treatment is ineffective. Candles are injected into the anus from 1 to 3 times a day, preferably after cleaning the rectum, as in this case, the use of the drug will be more effective. Candles with papaverine can be used either daily, courses up to 10 days, or symptomatically, if complaints occur. Long-term (more than 10 days) daily use of papaverine is not recommended, as it can cause allergies, hypotension, nausea, dizziness, excessive sweating, gastrointestinal disturbances.