Pradaxa is a drug that belongs to the group of anticoagulant and antithrombotic drugs. They use it in orthopedics and traumatology in the postoperative period mainly for the prevention of venous thromboembolism.
Feasibility of using Pradax
The main active substance of this drug is dabigatran etexilate. Due to this, thrombin activity is suppressed after applying the Pradax preparation. Dabigatran etexilate is rapidly absorbed and transformed into dabigatran (reversible direct thrombin inhibitor) during hydrolysis. The effectiveness of the drug is reduced by 20% if the weight of a person is more than 120 kg, and increases by 25% with a body weight of the patient less than 48 kg.
Indications for use Pradax are:
- prevention of venous thromboembolism;
- prevention of various systemic thromboembolism ;
- prevention of cardiovascular disease in patients with atrial fibrillation.
The use of Pradax is shown to practically all patients with such diagnoses after orthopedic operations, since of all modern coagulants this drug is considered to be the most effective. Also, this medication is prescribed after a knee joint endoprosthetics. Reception for a quick recovery of the body should start 1-4 hours after the end of the operation.
Contraindications to the use of Pradaxi
Even if you have indications for the use of Pradax's medication, you can not use it in treatment for hypersensitivity to any components of the drug. Do not start taking the medication with severe form of kidney failure, spontaneous or induced disturbance of homeostasis and with clinically significant bleeding.
Contraindications to the use of Pradax are also:
- impaired liver function;
- trauma of the spine and brain;
- malignant neoplasms;
- intracranial hemorrhage;
- gastrointestinal ulcer;
- intracerebral vascular disorders.
It is not recommended to use this drug simultaneously with antiplatelet agents. This combination is dangerous for life, since it significantly increases the risk of bleeding almost threefold. If there is evidence for the use of Pradax and the doctor decided to prescribe this medicine, then it is necessary to cancel the intake of any other types of anticoagulants. It is not recommended to perform treatment with such medication for patients under 18 years of age, since no clinical data on the results of its use at this age are available.