De-Nol is an effective pharmaceutical preparation used to treat diseases of the gastrointestinal tract. Medication helps to strengthen the protection of the epithelium of the gastric mucosa and its regeneration after damage by hydrochloric acid produced by the body. The peculiarity of the drug De-Nol is its antimicrobial action against the chylobacter pylori - a bacterium that causes gastritis, stomach and duodenum ulcers.
Analogs and Substitutes of De-Nol
Analogues of De-Nol tablets according to the active ingredient are:
- Novobispol;
- Biskol;
- Biscol-Citrate;
- Ventrisol;
- Vis-Nol;
- Duosol;
- Tribimol;
- Ulceron.
The composition of these preparations includes bismuth tricalium dicitrate. As well as De-Nol, its analogs have astringent, anti-inflammatory and antimicrobial effects. In the acidic environment of the stomach, the active substance, when combined with the protein substrate, forms a protective film on the surface of erosions and ulcerous formations.
A similar therapeutic effect is possessed by nonstructural analogues of the drug De-Nol, belonging to the same pharmacological group of gastroprotectors. The most popular among them are:
- Sucralfate;
- Carbenoxolone;
- Misoprostol;
- Alsukral;
- Sukrat;
- Ulgastan and others.
Let's give a comparative description of nonstructural analogues of de-Nol medicine.
Sucralfate
Sucralfate (or Venter) contains in its composition an active substance - an aluminum salt, so that the drug neutralizes bile acids. But in this case the drug is ineffective in the fight against hylebacter pylori, does not form a protective barrier on the epithelium of the walls of the stomach. In addition, Sucralfate has more side effects and contraindications to use. So, in addition to general prohibitions, tablets should also not be used in the treatment of children under 4 years of age, dysphagia or obstruction of the gastrointestinal tract, bleeding of the gastrointestinal tract.
Carbenoksolon
Carbenoksolon (or biogastron) contains an active substance - an extract from the roots of licorice. The drug helps to increase secretory mucus secretion of the stomach while increasing its viscosity, which best affects the formation of a protective barrier. At the same time there are adverse side effects in the form of hypertension, swelling of limbs and washing out of potassium from the blood.
Misoprostol
Synthetic drug Misoprostol belongs to the group of prostaglandins - hormone-like agents. Misoprostol significantly improves blood flow in the capillaries of the gastric mucosa, increases the formation of mucus, while reducing the release of pepsin. As well as De-Nol, misoprostol accelerates regenerative processes in gastritis and gastric ulcer, as well as in the duodenum. When taking the drug, side effects are possible, similar to those that occur with the application of De-Nol.
The comparative cost of the drug De-Nol and its analogues
It is worth emphasizing that many analogues of De-Nol are much cheaper. For example, the cost of a popular structural analogue of De-Nol drug Novobismol, on average, is $ 13, while the price of tablets De-Nol in pharmacy chains is 1.5 times higher - about 18 cu. Almost twice cheaper is another structural analogue of Vis-Nol tablets.
Most analogues of De-Nol, belonging to the group of gastroprotectors, costs even less. So, the cost of Sucralfate (Venter) is about 4 cu. An exception is Misoprostol. This is quite an expensive drug, the price of a package with three tablets reaches $ 50.