Violation of the processes of formation of bile and its production leads to an insufficient intake of biological substance into the bile ducts. This condition, intrahepatic cholestasis, with timely therapy does not cause irreversible consequences. However, the chronic course of the pathology can provoke other serious diseases.
Causes of intrahepatic cholestasis syndrome
Factors contributing to the deterioration of bile synthesis:
- hypothyroidism ;
- sepsis;
- taking certain medicines;
- Alagill's syndrome;
- hepatitis;
- chromosomal disorders;
- congenital pathologies of metabolism;
- endocrine diseases;
- hormonal imbalance in pregnancy;
- alcoholism;
- cirrhosis of the liver;
- intoxication;
- bacterial infections;
- intestinal dysbiosis;
- endotoxemia.
Symptoms and signs of intrahepatic cholestasis
To early clinical manifestations of the cholestatic syndrome include pruritus and jaundice.
The main symptomatology:
- fecal decoloration;
- darkening of urine;
- enlargement of the liver in size;
- "Fat" feces;
- dyspeptic disorders;
- a feeling of bitterness in the language;
- sometimes - pain or heaviness under the right lower rib.
Treatment of intrahepatic cholestasis
Therapy of the described syndrome is aimed at eliminating the primary cause of cholestasis.
Simultaneously, a treatment is provided that helps to alleviate the symptoms in each specific case. Appointments are performed only by a specialist in accordance with the diagnosis, results of analyzes, instrumental studies.
For the preparation of the therapeutic regimen, the following drugs are used:
- Heptral ;
- Ursosan;
- Rifaren;
- Ursofalk;
- Naloxone;
- Rifampicin;
- ursodeoxycholic acid;
- Metronidazole;
- Rifadine;
- Nalmefer;
- Flumecinol;
- Cholestyramine;
- Bilignin;
- Zixorin;
- Ondansetron.
It is also important to observe a diet with restriction of animal fats, intake of vitamins.